Artificial Pancreas Algorithm Project

About this project

The Artificial Pancreas Algorithm project is seeking people highly motivated to control an insulin pump with blood glucose data from a continuous blood glucose sensor. It's being studied elsewhere, but our algorithm will be different: we too will "close the loop" to control the basal rate of the insulin pump and drive the blood glucose level toward a target value, but we will additionally use state-based behavior to know when the closed-loop approach will perform better than the existing predictive approach and when it will not. We will also use adaptive variables and CGMS feedback for the purpose of "learning" the basal rates and C/I ratios and insulin sensetivity factors unique to each pump user. With a balance of the closed-loop approach and the predictive approach, we get the most out of the insulin pumps and GCMS sensors that we already have. It will be like having your own expert CDE built into your pump, and we can do this right now.

Motivation for an Artificial Pancreas

• A Patient's Story
• A Parent's Story
• A Caregiver's Story

Seeking New Members

• Who We Need
• What can I do, where is help needed?
• How To Join
• Members List

Articles Explaining How We Can Do It

• What does it REALLY MEAN to close the loop from the CGMS to the insulin pump?
• Optional reading: Help with these funny bubble diagrams
• How will states and modes be used to control an insulin pump?
• Adaptive Variables, Adaptive Filtering
• Example: how will the algorithm "Learn" the basal rate?
• The JDRF Computer Simulation Tool for Algorithm Development

Articles Actually Doing It

• Hatley-Pirbhai Functional Decomposition (under construction)
• Statemate (under construction)
• Simulink (under construction)

Helping out

• We need encouragement! Let us know you care by leaving a note on any author's "talk" page.
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Not sure where to start?

• Find out more about the wiki on the About page.
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Adding content

• Every wiki has two list of articles that need help called "Stubs" and "Wanted Articles". Don't be shy, get in there.
• Uploading images is another really easy way to help out - see the Special:Upload page!
• You can find a list of useful templates on Category:Templates, some of which are documented on the templates project page.

Talk and more...

• Check out the community portal to see what the community is working on, to give feedback or just to say hi.

Help! My pancreas sucks.

Background

Need the Big Picture? Read this:

• Endocrine physiology
• Insulin pump therapy
• Development of CGMS
• The "closed-loop" concept for an Artificial Pancreas
• A story problem just for fun
• Insulin pump control variables
• Expert Control
• Feedback of real-time blood glucose data to an insulin pump for bolus control
• Insulin and amylin combination
• Glucagon combination
• Further reading