About this project

The Artificial Pancreas Algorithm project is seeking people highly motivated to control an insulin pump with blood glucose data from a continuous blood glucose sensor. It's being studied elsewhere, but our algorithm will be different: we too will "close the loop" to control the basal rate of the insulin pump and drive the blood glucose level toward a target value, but we will additionally use state-based behavior to know when the closed-loop approach will perform better than the existing predictive approach and when it will not. We will also use adaptive variables and CGMS feedback for the purpose of "learning" the basal rates and C/I ratios and insulin sensitivity factors unique to each pump user. With a balance of the closed-loop approach and the predictive approach, we get the most out of the insulin pumps and CGMS sensors that we already have. It will be like having your own expert CDE built into your pump, and we can do this right now.

Motivation for an Artificial Pancreas

• A Patient's Story
• A Parent's Story
• A Caregiver's Story

Seeking New Members

• Who We Need
• What can I do, where is help needed?
• How To Join
• Members List

Background Topics

• Endocrine physiology
• Insulin pump therapy
• Development of CGMS
• The "closed-loop" concept for an Artificial Pancreas
• A story problem just for fun
• Insulin pump control variables
• Expert Control
• Feedback of real-time blood glucose data to an insulin pump for bolus control
• Insulin and amylin combination
• Glucagon combination
• Further reading

Articles Explaining How We Can Close the Loop Right Now

• What does it REALLY MEAN to close the loop from the CGMS to the insulin pump?
• "Strike the Spike:" or THIS IS WHY the PID algorithm will never outperform a good prediction combined with a pre-bolus and closed loop correction
• Optional reading: Help with these funny bubble diagrams
• How will states and modes be used to control an insulin pump?
• Adaptive Variables, Adaptive Filtering
• Example: how will the algorithm "Learn" the basal rate?
• The JDRF Computer Simulation Tool for Algorithm Development

Working Pages

• Hatley-Pirbhai Functional Decomposition (under construction)
• Statemate (under construction)
• Simulink (under construction)

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